Buy Dapoxetine Online Australia
Dapoxetine is a unique, short-acting, selective serotonin reuptake inhibitor (SSRI). It is clinically proven that the drug is effective in the treatment of premature ejaculation in men aged 18 years and older. Approximately from 27 to 34% of men of all age groups suffer from premature ejaculation, taking Dapoxetine prolongs the duration of sexual intercourse by 3-4 times.
Dapoxetine - the mechanism of action of the drug during premature ejaculation is associated with inhibition of serotonin reuptake by neurons with subsequent enhancement of the neurotransmitter effect on pre- and postsynaptic receptors. The mechanism of ejaculation is regulated mainly by the sympathetic nervous system. Postganglionic sympathetic nerve fibers innervate the seminal vesicles, vas deferens, prostate gland, muscles of the urethra and bladder neck, causing their coordinated contraction to achieve ejaculation.
Dapoxetine affects the ejaculation reflex, increasing the latent period and reducing the duration of the reflex impulses of the motor neurons of the perineal ganglia. The stimulus that triggers ejaculation is generated in the spinal reflex center, which through the brain stem is controlled by several nuclei of the brain, including the preoptic and paraventricular.
The pharmacokinetics of Dapoxetine are rapidly absorbed, and the maximum plasma concentration (Cmax) is reached within 1-2 hours after taking the drug. Intake of fatty foods moderately reduces Cmax of dapoxetine (by 10%) and increases AUC and the time to reach maximum plasma concentration by 12%. However, the degree of absorption of dapoxetine does not change. These changes are not clinically significant. Dapoxetine can be taken regardless of the meal. Over 99% of dapoxetine is bound to plasma proteins. The active metabolite, desmetildadoxetin, is bound to 98.5% of plasma proteins. Dapoxetine is rapidly distributed throughout the body with an average equilibrium distribution volume of 162 liters.
Studies suggest that dapoxetine is metabolized by many liver and kidney enzymes, especially CYP2D6, CYP3A4, and flavin-containing monooxygenase (FM01) of the kidneys. In a clinical study, during which the metabolism of 14C-dapoxetine was studied, dapoxetine after oral administration was extensively metabolized mainly by N-oxidation, N-demethylation, hydroxylation of the naphto group, glucuronization, and addition of the sulfo group. After oral administration, signs of presystemic metabolism were found in the liver. The main components circulating in the blood plasma were intact dapoxetine and dapoxetine-N-oxide. Studies have found that dapoxetine-N-oxide is inactive.
Ejaculation is a complex physiological process that combines two processes - emission and, actually, ejaculation. The emission phase is the result of a reflex response from the nervous system (and reflexes, if you remember, depend on our will very limitedly).
This occurs after erotic stimulation (visual or during direct contact). In the emission phase, sperm is released into the lumen of the urethra due to a reduction in the vas deferens, seminal vesicles and the prostate. While the sensation of approaching ejaculation increases, the possibility of volitional control progressively decreases, reaching a certain point when ejaculation cannot be stopped.
Immediately after the emission follows the expulsion phase - also the result of the unconditional, i.e. not amenable to volitional control reflex. In this phase, the internal sphincter of the bladder closes in order to prevent the return of the semen. After that, the external sphincter opens, and the sperm is thrown out due to the contraction of the pelvic floor muscles.
If you dig even deeper, then at the biochemical level, ejaculation is an even more complex process. I do not urge you to memorize these complex names, I will designate them only so that you can imagine how difficult it is for even a very competent doctor to understand why this or that man had this problem.
Instructions for use of the drug Priligi
Priligi (Priligy) is an effective remedy for the treatment of premature ejaculation in men and prolongs the duration of sexual intercourse from a leading Italian manufacturer. The use of the drug normalizes the work of sexual function in men, and the active active ingredient (dapoxetine) normalizes the reflex function of ejaculation.
Composition. The preparation contains the active substance dapoxetine in dosages of 30 or 60 mg (depending on the form of release) and excipients (film coat): monocrystalline cellulose, lactose monohydrate, silicon dioxide, magnesium stearate.
Release form. The drug Priligi comes in the form of gray tablets, having a convex shape on both sides in a film shell. On the one hand, on each tablet, the number of the active substance contained in the triangle is squeezed out; on the other, a cross section in which the white contents are clearly visible. The tablets have a package of blisters with a quantity of 3 or 6 pcs.
Pharmachologic effect. The principle of action of dapoxetine on premature ejaculation is associated with the mechanism of inhibition and capture of serotonin by neurons, and the effect on the receptors is enhanced. Ejaculation is a process that is regulated in the sympathetic nervous system: coordinated contraction of nerve fibers that activate the sperm and the prostate gland, triggers the ejaculation process. Dapoxetine acts directly on the ejaculation reflex, prolonging the latent period, reducing the impulses of neurons in the perineum.
Contraindications to Dapoxetine
- hypersensitivity to dapoxetine or any auxiliary component of the drug;
- severe heart disease (for example, NYHA grade 2-4 class of heart failure, impaired cardiac conduction (AV-block 2-3 degrees or sinus node weakness syndrome (SSS)) in the absence of a permanent pacemaker, severe ischemic heart disease or valvular lesion);
- simultaneous reception of MAO inhibitors and reception within 14 days after the termination of their use. Similarly, MAO inhibitors should not be taken within 7 days after discontinuation of dapoxetine;
- simultaneous administration of thioridazine and for 14 days after discontinuation of its use. Similarly, thioridazine should not be taken within 7 days after discontinuation of dapoxetine;
- simultaneous administration of serotonin reuptake inhibitors (selective serotonin reuptake inhibitors - SSRIs), serotonin and noradrenaline reuptake inhibitors, and tricyclic antidepressants and other drugs that have serotonergic effects (for example, L-tryptophan, triptans, tramadol, glyph, glyph, and chyrophrine cytosis. (Hypericum perforatum) and for 14 days after stopping these drugs. Similarly, these drugs should not be taken within 7 days after stopping the drug Dapoxetine;
- concomitant use with active CYP3A4 inhibitors, for example, ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone, nelfinavir, atazanavir, etc.,
- moderately severe liver function impairment;
- severe renal impairment;
- children and adolescents younger than 18 lactose intolerance;
How often do men have problems with ejaculation?
Some time ago, more than twelve thousand men from 18 to 70 years old were interviewed in the USA, Germany and Italy, and it turned out that premature ejaculation is a problem for almost one in four! (more precisely, it occurs in 22.7% of men).
As it turned out, men experiencing problems with ejaculation, more often than others complain of erectile dysfunction, decreased sexual desire, depression, anxiety, orgasm disorders. At the same time, only every tenth went to the doctor, and of those who tried to be treated, more than 90% are not happy with the results.
At what age do ejaculation problems most often occur?
According to a survey of a large number (to be more precise - 12 thousand 133) men - in any. From young to old. Only in the age group from 18 to 24 years old men with PE are slightly less (according to “scientific” speaking, statistically significantly less).
Does it matter: married or single? It turns out it has. In married men (or living in pairs), PE is more common, but only by 7%. But married people live longer ...
Pharmacodynamics (principle of action) of the drug
Dapoxetine Priligy is rapidly absorbed and reaches its maximum plasma concentration after one to two hours after ingestion. Eating foods enriched with fats moderately reduces the maximum concentration of dapoxetine and the time it takes to reach blood plasma. At the same time, there is no effect on the degree of absorption of the substance. The drug can be taken regardless of the meal.
Dapoxetine is removed from the body in a short time - after a day the maximum plasma content of the drug is less than 5-6% of the maximum (from the moment of taking the drug).
Indications for use.Dapoxetine Priligy is intended for the treatment of premature ejaculation in men aged 18 to 65 years.
ContraindicationsTaking the drug Priligy Dapoxetine is contraindicated in the following cases:
- Sensitivity to the constituent substances of the drug or dapoxetine.
- Heart diseases: valve damage, heart failure, grades 2-4.
- When violations of the liver and kidneys.
- Persons under 18 years.
- Individual lactose intolerance.
- It is strictly forbidden to take Dapoxetine for two weeks after the use of MAO inhibitors, as well as to take MAO inhibitors within one week after you finish taking Priligi. This also applies to the intake of CYP3A4 inhibitors (ritonavir, itraconazole, nefazodone, etc.).
Special instructions.General Dapoxetine is intended only for men with premature ejaculation. The safety of the drug in men without premature ejaculation has not been established, there is no evidence of delayed ejaculation. A randomized, double-blind, placebo-controlled study confirmed the efficacy of dapoxetine for the treatment of premature ejaculation (PE). Dapoxetine 60 mg significantly improves the average intravaginal delay of ejaculation (IELT) compared with Dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. Dapoxetine increases the sense of control and sexual satisfaction in men aged 18 to 64 years with PE.
Taking together with narcotic drugs.Patients should be advised not to take Dapoxetine along with narcotic drugs. Simultaneous administration of Dapoxetine with drugs with serotonergic activity, for example, ketamine, methylenedioxymethamphetamine (MDMA) and lysergic acid diethylamide (LSD), can lead to potentially serious reactions, including, but not limited to, arrhythmia, hyperthermia, and serotoninovymi, including, but not limited to, arrhythmias, hyperthermia, and serotoninovymi, including, but not limited to, arrhythmias, hyperthermia, and serotoninovi Dapoxetine in conjunction with sedatives, such as opiates or benzodiazepines, may increase drowsiness and dizziness.
Ethanol (alcohol).The combination of Dapoxetine with alcohol may enhance the effect of the latter on the central nervous system and the neuro-cardiogenic side effects of alcohol, such as fainting, which increases the risk of accidental injury. Therefore, patients should be advised to refrain from taking alcohol while taking Dapoxetine.
Syncope. The frequency of syncope in clinical studies of the drug Dapoxetine depended on the category of patients and ranged from 0.06% (for a dose of 30 mg) to 0.23% (for a dose of 60 mg) to 0.64% (for both doses together) study involving healthy volunteers.
Patients who received the drug Dapoxetine, compared with patients receiving placebo, were more likely to have prodromal symptoms, including nausea, dizziness / feeling of lightness in the head and sweating. With a dose of Dapoxetine 30 mg, the frequency of nausea was 11.0%, the frequency of vertigo — 5.8%, hyperhidrosis — 0.8%. With the dose of Dapoxetine 60 mg, these figures were 21.2%, 11.7% and 1.5%, respectively. The frequency of syncope and possible prodromal symptoms was dose-dependent, as evidenced by higher rates in patients who received higher doses than the maximum recommended daily dose of 60 mg. The cases of a syncope observed in clinical trials were regarded as having the vazo-vagal nature. Most of these cases occurred during the first 3 hours after the first dose, or were associated with conducting research procedures in a clinical setting (for example, taking a blood sample, rising sharply, measuring blood pressure). Possible prodromal symptoms, such as nausea, dizziness, a feeling of lightness in the head, palpitations, asthenia, confusion and sweating, were usually also observed in the first 3 hours after taking the drug and often preceded fainting.
Patients should be informed that during the period of treatment with the drug Dapoxetine at any time may develop fainting with prodromal symptoms or without them. The physician should inform the patient of the importance of sufficient water load and of recognizing prodromal signs and symptoms to reduce the risk of serious injury from falling due to loss of consciousness. When possible prodromal symptoms appear, the patient should immediately lie down so that the head is lower than the body, or sit with the head between the knees, and must remain in this position until the symptoms disappear. If fainting or other effects from the patient's central nervous system occur, the patient should be warned about the need to avoid potentially traumatic situations, including driving a car and controlling dangerous machinery.
The combination of dapoxetine with alcohol can increase neuro-cardiogenic side effects, including syncope, which increases the risk of accidental injury; therefore, patients should be advised to refrain from taking alcohol during the period of treatment with Dapoxetine.
Physiological causes of premature ejaculation
It should be noted that the increased sensitivity of the glans penis is one of the most common causes of premature ejaculation.
Increased sensitivity of the glans penis can be either congenital or acquired (for example, due to a postponed balanitis or phimosis).
In such cases, the man can choose one of two things: either use condoms and anti-aesthetics with prolonged action, or decide on a circumcision operation.
In cases where the increased sensitivity of the glans penis is caused by a postponed balanitis (inflammation of the skin of the penis) or phimosis (festering of the inner side of the foreskin), circumcision may also be indicated for medical reasons.
Other physiological causes of premature ejaculation are chronic vesiculitis, inflammation of the seminal vesicles - vesicles.
Because of the pathological process, the sensitivity of the walls of the vesicles is increased, and they may begin to contract faster than usual, as a result of which the seed rushes “out” too early.
Premature ejaculation as a result of chronic vesiculitis occurs irregularly, in contrast to premature ejaculation due to increased sensitivity of the glans penis. However, with chronic vesiculitis, ejaculation may be accompanied by painful sensations, and the feeling of orgasm may dull. Lubricants and condoms in such cases do not prevent premature ejaculation.
Given that chronic vesiculitis, as a rule, develops on the background of prostatitis and / or other inflammatory diseases of the genital sphere, it is better to consult a doctor with such symptoms. Having diagnosed (using urethroscopy) and making a diagnosis, our specialists will take all the necessary measures to provide you with effective assistance, depending on the specific causes of premature ejaculation.